How often is SDE content updated?

The deep dive library and Q&A Hub are reviewed and updated when significant new evidence changes the clinical guidance. The cardiovascular pharmacology space moves quickly: the SELECT trial (2023), the colchicine LoDoCo2 approval (2023), ongoing GLP-1 trials, and the expected results from tirzepatide cardiovascular outcomes studies will each require content updates as results arrive.

Honesty Scale ratings are the most likely elements to update, a claim rated Early (3) when this Hub was written may advance to Promising (2) or Solid (1) as new trial data confirms or disconfirms the mechanism. Updates are dated and noted in each article. The lastUpdated date in the JSON metadata for each Q&A pair reflects the most recent substantive revision.

What to do: Check the lastUpdated field on deep dives when making clinical decisions. Content that is more than 18 months old in a rapidly evolving area (GLP-1 drugs, colchicine, Lp(a) therapeutics) may have been superseded by new evidence.