CGM for Non-Diabetics
My CGM glucose trace looks normal but I have high triglycerides. What does that mean?
It means your CGM is showing you the output of a system that is already compensating. High triglycerides in a man with normal fasting glucose and good time in range often signals elevated fasting insulin: your pancreas is producing enough insulin to maintain the glucose curve your CGM shows, but at a metabolic cost that your triglycerides reflect. The CGM sees the result; it cannot see the work being done behind the scenes.
Elevated triglycerides, particularly above 150 mg/dL, indicate elevated VLDL particles, which are atherogenic. They are also a marker of insulin resistance that precedes glucose dysregulation. This is the sequencing cardiologists have been trained to recognize: triglycerides rise first, then fasting glucose climbs, then HbA1c eventually follows. The CGM enters the picture after several of these dominoes have already fallen. (Ginsberg HN, Endocrinology and Metabolism Clinics of North America, 200070136-4))
Cardiologist's calibrated position, Solid (1) for elevated triglycerides as an independent cardiovascular risk signal that CGM cannot capture. This is established lipid biochemistry, not an emerging finding.
What to do: Add a fasting insulin test to your next blood draw. A fasting insulin above 10 mIU/mL in a man with normal glucose confirms compensated insulin resistance. If VLDL-triglycerides are above 150 mg/dL, ApoB will likely be elevated even if LDL appears acceptable. Get the number directly.
For the full picture, read The CGM on Your Arm Doesn't Know Your Arteries.
Deep Dive
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